The development in large scale of lacustrine sediments or their deficiency in geologic history of the earth is closely related to the definite geostructural background and climatic conditions. According to the temporal-spatial distribution of lacustrine deposits since late-cenozoic, the evolutionary processes of macroenvironments are discussed in this paper. There exist a great number of large lakes in West China, with a thick pliocene and Early pleistocene deposits in the lakes, whereas only limited lake sediments were found in East China. This situation was resulted from the different structual movement and air circulation, with a rather humid climate in West China at that time. In mid-late Pleistocene, most of large lakes in West China shrunk quickly or even disappeared, while the tendancy of increasing and expanding of lake occurred in East China, which was evidently related to the rapid uplifting of Qingzhang Plateau and strengthening of East Asian monsoon. The lake response to in climatic zones giaciation and interglaciation since Last glacial age shows rel-ativeiy obvious differentiation indicating the influences of global, regional and local ronments respectively.