Along with the rapid development in developed areas, rapid expansion of construction land has caused changes of underlying surface hydrological conditions which could be an important factor for deterioration of water environment, and trigger series of environmental problems. In recent years, in order to coordinate the relationship between environment and economic development, many studies on spatial potential development regionalization have been carried out, which provides scientific basis and regulations for regional government on construction sprawl control. But most of these studies chose single administrative region as object, which lacks geographical unit of regional zoning across various administrative, and neglects the integrity of development with resource protection. The present study, based on existing related regionalization method, discusses the method of choosing indicators and evaluation in the scale of basin area. As a case study, Taihu Basin is divided into four types:high suitable areas, medium suitable areas, low suitable areas and non-suitable areas. By using data envelopment analysis method, the present study has explored the correspondence relationships between construction land, resource environmental capacity and development potential, and the unbalance situation of construction land distribution is assessed. The result can provide scientific basis for coordinating economic development and natural resources management, and making polices of space governance.