Water resources, economy and ecology are important components of the high-quality development of our society. In order to facilitate the coordinated development of high-quality water resources, economy and ecology, taking the Yellow River Basin in Henan Province as an example, we collected a long series of data on 27 indicators for 3 subsystems. We also clarified the relationship between the current value of the indicator and the target value, explored the temporal and spatial distribution characteristics of 27 indicators, used the combined weight method to determine the weight of the 27 indicators, and established the evaluation model of the water-economy-ecosystem coupling coordination degree of the Yellow River Basin in Henan Province. Then we used the ARIMA-GM combined model to predict the development trend of the degree of coupling and coordination from 2021 to 2025. The results showed:(1) The comprehensive evaluation index of water resources-economy-ecosystem of the Yellow River Basin in Henan Province showed an upward trend from 2000 to 2019. Among them, the comprehensive evaluation index of economic subsystems rose the fastest among the three subsystems. (2) The water-economy-ecosystem coupling coordination degree of the Yellow River Basin in Henan Province is on the rise, reaching 0.8105 in 2019, which is a good state of coordination. (3) Using the ARIMA-GM combined model to predict by scenario, it is found that scenario 4 has the greatest relative improvement, and its coupling coordination degree will be 0.9394 in 2025, reaching the high-quality coordinated development category. The Yellow River Basin in Henan Province should improve water resource utilization efficiency, strengthen ecological protection, and expand the space for high-quality urban development on the basis of rapid economic development.